Alternative Names:

C-JUN N-terminal kinase kinase 1, Dual specificity mitogen-activated protein kinase kinase 4, EC 2.7.12.2, JNK activating kinase 1, JNK kinase 1, JNKK, JNKK 1, JNKK1, MAP kinase kinase 4, MAP2K4, MAPK/ERK kinase 4, MAPKK 4, MKK4, MP2K4, PRKMK4, SAPK/ERK

Application:

WB

Reactivity:

Human, Mouse, Rat

Dilution:

WB 1:500-1:2000

	Western blot analysis of SEK1/MKK4 expression in NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

Purification:

Affinity-chromatography

Specificity:

SEK1/MKK4 Antibody detects endogenous levels of total SEK1/MKK4

Immunogen:

A synthesized peptide derived from human SEK1/MKK4

Description:

MKK4 dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38 but not ERK1 or -2. Mediates cellular responses to various cellular stresses and inflammatory cytokines. Phosphorylation by Akt inhibits MKK4 and suppresses stress-activated signal transduction.