Alternative Names:

ADA17, ADAM 17, CD156b antigen, CSVP, EC 3.4.24.86, TACE, TNF-alpha convertase, TNF-alpha-converting enzyme, a disintegrin and metalloproteinase domain 17, snake venom-like protease

Application:

WB

Reactivity:

Human, Mouse, Rat

Dilution:

WB 1:500-1:1000

	Western blot analysis of ADAM 17 expression in HT1080 whole cell lysates.

Purification:

Affinity-chromatography

Specificity:

ADAM 17 Antibody detects endogenous levels of ADAM 17 .

Immunogen:

A synthesized peptide derived from human ADAM 17 .

Description:

This gene encodes a disintegrin and metalloprotease (ADAM) domain 17, which is a member of the ADAM protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The member encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. This gene contains 19 exons and alternative splicing generates 2 transcripts.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.