Alternative Names:

ERBB1, Epidermal growth factor receptor precursor;Receptor protein-tyrosine kinase ErbB-1; kinase EGFR; HER1; EGFR; SA7; NISBD2;

Application:

WB IHC ICC/IF

Reactivity:

Human Mouse

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

	Western blot analysis of EGFR phosphorylation expression in A431 cell lysate treated with EGF.
	Immunohistochemical analysis of paraffin-embedded human breast cancer, using Phospho-EGFR (Y1068) Antibody .

Purification:

Affinity-chromatography

Specificity:

Phospho-EGFR (Y1068) Antibody detects endogenous levels of total Phospho-EGFR (Y1068)

Immunogen:

A synthesized peptide derived from human Phospho-EGFR (Y1068)

Description:

Receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. . A single-pass transmembrane tyrosine kinase. Ligand binding to this receptor results in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecules and lysosomal degradation. Can be phosphorylated and activated by Src.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.