Alternative Names:

AURA17;Dardarin; LRRK2; LRRK 2; PARK8; RIPK7; ROCO2;

Application:

WB ICC/IF

Reactivity:

Human Mouse

Dilution:

WB 1:500~1:1000 ICC/IF 1:50~1:200

	Western blot analysis of Filamin A phosphorylation expression in WT-LRRK2 cell lysate treated LRRK2.

Purification:

Affinity-chromatography

Specificity:

Phospho-LRRK2 (S935) Antibody detects endogenous levels of total Phospho-LRRK2 (S935)

Immunogen:

A synthesized peptide derived from human Phospho-LRRK2 (S935)

Description:

The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.