Alternative Names:

A5 protein; BDCA4; CD304 ; Neuropilin1; NP1; NPN1; NRP1; VEGF165R ; NEL like protein 1; Blood dendritic cell antigen 4 ;

Application:

WB IHC ICC/IF IP FC

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:50

	Western blot analysis of Neuropilin 1 expression in mouse heart lysate.
	Immunohistochemical analysis of paraffin-embedded human melanoma, using Neuropilin 1 Antibody .

Purification:

Affinity-chromatography

Specificity:

Neuropilin 1 Antibody detects endogenous levels of total Neuropilin 1

Immunogen:

A synthesized peptide derived from human Neuropilin 1

Description:

The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.