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Details
Alternative Names:
NOTC1, NOTCH1, TAN1, hN1, neurogenic locus notch homolog protein 1, neurogenic locus notch homolog protein 1 precursor,
Application:
WB IHC ICC/IF FC
Reactivity:
Human Mouse
Dilution:
WB 1:500~1:3000 IHC 1:50~1:200 ICC/IF 1:100~1:500 FC 1:200~1:500
Western blot analysis of NOTCH1 expression in HEK293 cell lysate. | |
Immunohistochemical analysis of paraffin-embedded human liver, using Notch1 Antibody . | |
Immunofluorescent analysis of HeLa cells, using Notch1 Antibody . | |
Purification:
Affinity-chromatography
Specificity:
Notch1 Antibody detects endogenous levels of total Notch1
Immunogen:
A synthesized peptide derived from human Notch1
Description:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.
Storage Condition and Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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