Alternative Names:

CD61; GP3A; GPIIIa; Integrin beta-3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITB3; ITGB3;

Application:

WB IHC ICC/IF

Reactivity:

Human Mouse Rat

Dilution:

WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

	Western blot analysis of Integrin beta3 expression in human spleen lysate.
	Immunohistochemical analysis of paraffin-embedded human testis, using Integrin beta 3 Antibody .

Purification:

Affinity-chromatography

Specificity:

Integrin beta 3 Antibody detects endogenous levels of total Integrin beta 3

Immunogen:

A synthesized peptide derived from human Integrin beta 3

Description:

Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity).

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.