Alternative Names:

BWCR; BWS; KIP2; WBS; p57; p57 Kip2; WBS ; CDKN1C; Cyclin dependent kinase inhibitor 1C

Application:

WB IHC ICC/IF IP

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50

	Western blot analysis on HeLa cell using p57 Kip2 Antibody.
	Immunohistochemical analysis of paraffin-embedded rat kidney, using p57 Kip2 Antibody .
	Immunofluorescent analysis of HeLa cells treated with dexamethasone, using p57 Kip2 Antibody .

Purification:

Affinity-chromatography

Specificity:

p57 Kip2 Antibody detects endogenous levels of total p57 Kip2

Immunogen:

A synthesized peptide derived from human p57 Kip2

Description:

p27 Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Like its relatives, p57 Kip2 and p21 Waf1/Cip1, the ability to enforce the G1 restriction point is derived from its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes. Expression levels of p27 are upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.