Alternative Names:

RSK; HU-1; MAPKAPK1A; RPS6KA1;p90 RSK1; RPS6K1 ; RSK 1 p90; S6K alpha 1; 90 kDa ribosomal protein S6 kinase 1 Ribosomal S6 kinase 1;

Application:

WB IHC ICC/IF IP

Reactivity:

Human Mouse Rat

Dilution:

WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50

	Western blot analysis of RSK 1 p90 phosphorylation expression in K562 cell lysate treated with EGF.

Purification:

Affinity-chromatography

Specificity:

Phospho-RSK1 p90 (T359+S363) Antibody detects endogenous levels of total Phospho-RSK1 p90 (T359+S363)

Immunogen:

A synthesized peptide derived from human Phospho-RSK1 p90 (T359+S363)

Description:

Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine / threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.