Alternative Names:

FEX; GPR49; GPR67; GRP49; LGR5; HG38;8

Application:

WB IP FC

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 IP 1:50 FC 1:200

	Western blot analysis of GPR49 expression in Human fetal skeletal muscle lysate.

Purification:

Affinity-chromatography

Specificity:

LGR5/GPR49 Antibody detects endogenous levels of total LGR5/GPR49

Immunogen:

A synthesized peptide derived from human LGR5/GPR49

Description:

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.