Alternative Names:

BBC3; bcl2 binding component 3; jfy1; puma; p53 up-regulated modulator of apoptosis; PUMA alpha;

Application:

WB IHC ICC/IF FC

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 FC 1:50

	Western blot analysis of PUMA expression in K562 cell lysate.
	Immunohistochemical analysis of paraffin-embedded human breast cancer, using PUMA Antibody.
	Immunofluorescent analysis of Hela cells, using PUMA Antibody .

Purification:

Affinity-chromatography

Specificity:

PUMA Antibody detects endogenous levels of total PUMA

Immunogen:

A synthesized peptide derived from human PUMA

Description:

Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.