Alternative Names:

Interferon regulatory factor 1; IRF1; MAR;

Application:

WB IHC ICC/IF IP FC

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:1000 IHC 1:50~1:100 ICC/IF 1:50~1:100 IP 1:50 FC 1:50

	Western blot analysis of IRF1 expression in Jurkat cell lysate.
	Immunohistochemical analysis of paraffin-embedded rat kidney, using IRF1 Antibody.
	Immunofluorescent analysis of Hela cells, using IRF1 Antibody .

Purification:

Affinity-chromatography

Specificity:

IRF1 Antibody detects endogenous levels of total IRF1

Immunogen:

A synthesized peptide derived from human IRF1

Description:

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor. Defects in IRF1 are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer intestinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.