Alternative Names:

Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene; c-MAF; c-maf proto-oncogene; cMaf; MAF; MGC71685; Proto-oncogene c-Maf;

Application:

IHC

Reactivity:

Human Mouse Rat

Dilution:

IHC 1:50~1:200

	Immunohistochemical analysis of paraffin-embedded human kidney, using c-Maf Antibody.

Purification:

Affinity-chromatography

Specificity:

c-Maf Antibody detects endogenous levels of total c-Maf

Immunogen:

A synthesized peptide derived from human c-Maf

Description:

Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.