Alternative Names:

IGF2R; CI Man-6-P receptor; CI-MPR; M6PR; MPR 300; Insulin-like growth factor 2 receptor; M6P/IGF2R; CD222;

Application:

WB IHC ICC/IF IP FC

Reactivity:

Human Mouse Rat

Dilution:

WB 1:5000~1:20000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:30 FC 1:100

	Western blot analysis of extracts of M6PR expression in Jurkat cell lysate.
	Immunohistochemical analysis of paraffin-embedded human colon, using M6PR Antibody.

Purification:

Affinity-chromatography

Specificity:

M6PR Antibody detects endogenous levels of total M6PR

Immunogen:

A synthesized peptide derived from human M6PR

Description:

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.