Alternative Names:

KDM1;AOF2;BHC110;KIAA0601;LSD1; KDM1A;

Application:

WB IHC ICC/IF IP

Reactivity:

Human Mouse Rat

Dilution:

WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:30

	Western blot analysis of KDM1/LSD1 expression in Hela cell lysate
	Immunohistochemical analysis of paraffin-embedded human colon, using KDM1/LSD1 Antibody.

Purification:

Affinity-chromatography

Specificity:

KDM1 / LSD1 Antibody detects endogenous levels of total KDM1 / LSD1

Immunogen:

A synthesized peptide derived from human KDM1 / LSD1

Description:

Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.