Alternative Names:

ASH 2; ASH2; ASH2 LIKE; ASH2 like protein; ASH2-like protein; Ash2l; ASH2L1; ASH2L2; Bre 2; Bre2;

Application:

WB IHC ICC/IF

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

	Western blot analysis of ASH2L expression in K562 cell lysate.
	Immunohistochemical analysis of paraffin-embedded human kideny, using ASH2L Antibody.

Purification:

Affinity-chromatography

Specificity:

ASH2L Antibody detects endogenous levels of total ASH2L

Immunogen:

A synthesized peptide derived from human ASH2L

Description:

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.