Alternative Names:

ARNT;HIF-1beta;HIF1B;HIF1BETA;TANGO;bHLHe2;

Application:

WB IHC

Reactivity:

Human

Dilution:

WB 1:500~1:2000 IHC 1:500~1:2000

	Western blot analysis of HIF-1 beta expression in Human fetal kidney lysate.
	Immunohistochemical analysis of paraffin-embedded human colon, using HIF-1 beta Antibody .

Purification:

Affinity-chromatography

Specificity:

HIF-1 beta Antibody detects endogenous levels of total HIF-1 beta

Immunogen:

A synthesized peptide derived from human HIF-1 beta

Description:

HIF-1β is also known as AhR nuclear translocator (ARNT) due to its ability to partner with the aryl hydrocarbon receptor (AhR) to form a heterodimeric transcription factor complex. Together with AhR, HIF-1β plays an important role in xenobiotics metabolism. In addition, a chromosomal translocation leading to a TEL-ARNT fusion protein is associated with acute myeloblastic leukemia. Studies also found that ARNT/HIF-1β expression levels decrease significantly in pancreatic islets from patients with type 2 diabetes, suggesting that HIF-1β plays an important role in pancreatic β-cell function.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.