Alternative Names:

PP2A alpha; PP2A beta; Replication protein C; PPP2CA; PPP2CB;

Application:

WB IHC ICC/IF IP

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50

	Western blot analysis of PP2A alpha+beta expression in T47 D cell lysate.
	Immunohistochemical analysis of paraffin-embedded human colon, using PP2A alpha + beta Antibody.

Purification:

Affinity-chromatography

Specificity:

PP2A alpha + beta Antibodydetects endogenous levels of total PP2A alpha + beta

Immunogen:

A synthesized peptide derived from human alpha + beta PP2A

Description:

Protein phosphatase type 2A (PP2A) is an essential protein serine/threonine phosphatase that is conserved in all eukaryotes. PP2A is a key enzyme within various signal transduction pathways as it regulates fundamental cellular activities such as DNA replication, transcription, translation, metabolism, cell cycle progression, cell division, apoptosis and development. The core enzyme consists of catalytic C and regulatory A (or PR65) subunits, with each subunit represented by α and β isoforms.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.