Alternative Names:

RSK; HU-1; RSK1; MAPKAPK1A; RPS6KA1;

Application:

WB ICC/IF IP

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 ICC/IF 1:50~1:200 IP 1:50

	Western blot analysis of Phospho-RSK1(S380) expression in A431 cell lysate treated with EGF.

Purification:

Affinity-chromatography

Specificity:

Phospho-RSK1(S380) Antibody detects endogenous levels of total Phospho-RSK1(S380)

Immunogen:

A synthesized peptide derived from human Phospho-RSK1(S380)

Description:

Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine / threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.