Alternative Names:

ACAC; ACACA; ACACB; ACC; ACC-alpha; ACC1; ACC2; ACCA; ACCB; Acetyl-CoA carboxylase 1; Biotin carboxylase;

Application:

WB IHC

Reactivity:

Human Mouse Rat

Dilution:

WB 1:1000~1:2000 IHC 1:50~1:200

	Western blot analysis of Acetyl-CoA Carboxylase expression in A431 cell lysate.
	Immunohistochemical analysis of paraffin-embedded human kidney, using Acetyl-CoA Carboxylase Antibody.

Purification:

Affinity-chromatography

Specificity:

Acetyl-CoA Carboxylase Antibody detects endogenous levels of total Acetyl-CoA Carboxylase

Immunogen:

A synthesized peptide derived from human Acetyl-CoA Carboxylase

Description:

ACC1 a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Acetyl-CoA carboxylase (ACC) catalyzes the pivotal step of the fatty acid synthesis pathway. The 265 kDa ACCα (ACC1) is the predominant isoform found in liver, adipocytes, and mammary gland, while the 280 kDa ACCβ (ACC2) is the major isoform in skeletal muscle and heart.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.