Alternative Names:

CMH-1; ICE-LAP3; MCH3; CASP7; Caspase-7; Caspase7;

Application:

WB IHC IP

Reactivity:

Mouse Rat

Dilution:

WB 1:500~1:1000 IHC 1:50~1:200 IP 1:50

	Western blot analysis of Caspase-7 expression in NIH/3T3 cell lysate.

Purification:

Affinity-chromatography

Specificity:

Caspase-7 Antibody detects endogenous levels of Caspase-7

Immunogen:

A synthesized peptide derived from human Caspase-7

Description:

Caspase-7 (CMH-1, Mch3, ICE-LAP3) has been identified as a major contributor to the execution of apoptosis. Caspase-7 is an effector caspase (along with caspase-2 and -3), meaning that it cleaves essential cellular machinery rather than activating other caspases. Caspase-7 is cleaved by many enzymes, including caspases-3, -6, -8, -9 and granzyme B. Once activated, caspase-7 cleaves many of the same substrates as caspase-3, including poly (ADP-ribose) polymerase, or PARP.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.