Alternative Names:

TSC2; Tuberous sclerosis 2 homolog protein; Tuberous sclerosis 2 protein; Tuberin;

Application:

WB IHC FC

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 FC 1:50

	Western blot analysis of Tuberin expression in Jurkat cell lysate.
	Immunohistochemical analysis of paraffin-embedded human prostate carcinoma, using Tuberin Antibody.

Purification:

Affinity-chromatography

Specificity:

Tuberin Antibody detects endogenous levels of Tuberin

Immunogen:

A synthesized peptide derived from human Tuberin

Description:

Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. Tuberin is directly phosphorylated at Thr1462 by Akt/PKB. Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.