Alternative Names:

MCH2; CASP6; Caspase-6;

Application:

WB IHC ICC/IF IP

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:1000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50

	Western blot analysis of Caspase-6 expression in Jurkat cell lysate.
	Immunohistochemical analysis of paraffin-embedded human colon, using Caspase-6 Antibody.

Purification:

Affinity-chromatography

Specificity:

Caspase-6 Antibody detects endogenous levels of Caspase-6

Immunogen:

A synthesized peptide derived from human Caspase-6

Description:

Caspase-6 (Mch2) is one of the major executioner caspases functioning in cellular apoptotic processes. Upon apoptotic stimulation, initiator caspases such as caspase-9 are cleaved and activated. The activated upstream caspases further process downstream executioner caspases, such as caspase-3 and caspase-6, by cleaving them into large and small subunits, thereby initiating a caspase cascade leading to apoptosis. One of the major targets for caspase-6 is the membrane associated protein lamin A.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.