Alternative Names:

EC 2.7.10.1; ERBB1; Epidermal growth factor receptor precursor; kinase EGFR;

Application:

WB IHC ICC/IF IP

Reactivity:

Human

Dilution:

WB 1:500~1:2000 IHC 1:50~1:100 ICC/IF 1:50~1:100 IP 1:20

	Western blot analysis of Phospho-EGFR (Y1173) expression in A431 cell lysate treated with EGF.
	Immunohistochemical analysis of paraffin-embedded rat stomach, using Phospho-EGFR (Y1173) Antibody.

Purification:

Affinity-chromatography

Specificity:

Phospho-EGFR (Y1173) Antibody detects endogenous levels of Phospho-EGFR (Y1173)

Immunogen:

A synthesized peptide derived from human Phospho-EGFR (Y1173)

Description:

The epidermal growth factor (EGF) receptor is a transmembrane tyrosine kinase that belongs to the HER/ErbB protein family. Ligand binding results in receptor dimerization, autophosphorylation, activation of downstream signaling, internalization, and lysosomal degradation. The GRB2 adaptor protein binds activated EGFR at phospho-Tyr1068.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.