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Details
Alternative Names:
STK3; Mess1; MST-2; MST2; Serine/threonine kinase 3; KRS1; STE20-like kinase MST2;
Application:
WB IHC IP
Reactivity:
Human Mouse Rat
Dilution:
WB 1:1000~1:5000 IHC 1:50~1:100 IP 1:50
Western blot analysis of STK3 expression in HeLa cell lysate. | |
Immunohistochemical analysis of paraffin-embedded human kidney, using STK3 Antibody. | |
Purification:
Affinity-chromatography
Specificity:
STK3 Antibody detects endogenous levels of STK3
Immunogen:
A synthesized peptide derived from human STK3
Description:
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.
Storage Condition and Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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