Alternative Names:

PLC-148; PLC-II; PLC-gamma1; PLC1; PLCG-1; Phospholipase C-gamma-1;

Application:

WB ICC/IF IP

Reactivity:

Human Mouse Rat

Dilution:

WB 1:1000~1:5000 ICC/IF 1:50~1:200 IP 1:50

	Western blot analysis of PLC gamma 1 expression in Jurkat cell lysate.

Purification:

Affinity-chromatography

Specificity:

PLC gamma 1 Antibody detects endogenous levels of PLC gamma 1

Immunogen:

A synthesized peptide derived from human PLC gamma 1

Description:

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.