Alternative Names:

90 kDa ribosomal protein S6 kinase polypeptide 5; EC 2.7.11.1; KS6A5; MSPK1; Nuclear mitogen- and stress-activated protein kinase-1; RLPK; RPS6KA5; kinase MSK1; ribosomal protein S6 kinase;

Application:

WB IHC ICC/IF IP

Reactivity:

Human Rat

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF1:50~1:200 IP 1:50

	Western blot analysis of Phospho-MSK1 (S376) expression in HEK293 cell lysate treated with EGF.
	Immunohistochemical analysis of paraffin-embedded human lung cancer, using Phospho-MSK1 (S376) Antibody.

Purification:

Affinity-chromatography

Specificity:

Phospho-MSK1 (S376) Antibody detects endogenous levels of Phospho-MSK1 (S376)

Immunogen:

A synthesized peptide derived from human Phospho-MSK1 (S376)

Description:

Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.