Alternative Names:

hSIR2; hSIRT1; NAD-dependent deacetylase sirtuin 1; SIR1; SIR2-like protein 1;

Application:

WB IHC ICC/IF

Reactivity:

Human

Dilution:

WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

	Western blot analysis of Phospho-SIRT1 (S47) expression in (1) HEK293 cell lysate; (2) HEK293 cell lysate treated with LP.
	Immunohistochemical analysis of paraffin-embedded human colon, using Phospho-SIRT1 (S47) Antibody.

Purification:

Affinity-chromatography

Specificity:

Phospho-SIRT1 (S47) Antibody detects endogenous levels of Phospho-SIRT1 (S47)

Immunogen:

A synthesized peptide derived from human Phospho-SIRT1 (S47)

Description:

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.