Alternative Names:

SMAC; DFNA64; DIABLO; SMAC3;

Application:

WB IHC ICC/IF IP FC

Reactivity:

Human Mouse Rat

Dilution:

WB 1:1000~1:5000 IHC 1:50~1:200 ICC/IF 1:100~1:500 IP 1:50 FC 1:50

	Western blot analysis of Smac/Diablo expression in Jurkat cell lysate.
	Immunohistochemical analysis of paraffin-embedded human kidney, using Smac/Diablo Antibody.

Purification:

Affinity-chromatography

Specificity:

Smac/Diablo Antibody detects endogenous levels of Smac/Diablo

Immunogen:

A synthesized peptide derived from human Smac/Diablo

Description:

Smac/Diablo is a 21 kDa mammalian mitochondrial protein that functions as a regulatory component during apoptosis. Upon mitochondrial stress, Smac/Diablo is released from mitochondria and competes with caspases for binding of IAPs (inhibitor of apoptosis proteins). The interaction of Smac/Diablo with IAPs relieves the inhibitory effect of the IAPs on caspases.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.