Alternative Names:

BTK, AGMX1, AT, ATK, XLA, PSCTK1, B-cell progenitor kinase, BPK, Bruton tyrosine kinase, Tyrosine-protein kinase BTK, IMD1;

Application:

WB ICC/IF

Reactivity:

Human

Dilution:

WB 1:500~1:2000 ICC/IF 1:50~1:200

	Western blot analysis of Phospho-BTK (Y551) expression in Jurkat cell lysate treated with Pervanadate.

Purification:

Affinity-chromatography

Specificity:

Phospho-BTK (Y551) Antibody detects endogenous levels of Phospho-BTK (Y551)

Immunogen:

A synthesized peptide derived from human Phospho-BTK (Y551)

Description:

Bruton's tyrosine kinase (Btk) is a member of the Btk/Tec family of cytoplasmic tyrosine kinases. Like other Btk family members, it contains a pleckstrin homology (PH) domain and Src homology SH3 and SH2 domains. Btk plays an important role in B cell development. Activation of B cells by various ligands is accompanied by Btk membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.