Alternative Names:

Cell cycle regulated protein kinase; PLK 1; PLK; Polo like kinase 1 ; Serine/threonine protein kinase 13; Serine/threonine protein kinase PLK1; STPK 13;

Application:

WB

Reactivity:

Human

Dilution:

WB 1:1000~1:2000

	Western blot analysis of Phospho-PLK1 (T210) expression in (1) HeLa cell lysate; (2) HeLa cell treated with nocodazole lysate.

Purification:

Affinity-chromatography

Specificity:

Phospho-PLK1 (T210) Antibody detects endogenous levels of Phospho-PLK1 (T210)

Immunogen:

A synthesized peptide derived from human PLK1

Description:

Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.