Alternative Names:

NAD-dependent protein deacetylase sirtuin-1; hSIRT1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2; SirtT1 75 kDa fragment; 75SirT1; SIRT1; SIR2L1;

Application:

WB

Reactivity:

Human

Dilution:

WB 1:1000~1:2000

	Western blot analysis of Phospho-SIRT1 (T530) expression in (1) 293T cell lysate; (2) 293T cell treated with Calyculin A.

Purification:

Affinity-chromatography

Specificity:

Phospho-SIRT1 (T530) Antibody detects endogenous levels of Phospho-SIRT1 (T530)

Immunogen:

A synthesized peptide derived from human SIRT1

Description:

The Silent Information Regulator (SIR2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. SirT1 deacetylase activity is inhibited by nicotinamide and activated by resveratrol.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.