Alternative Names:

SIR2L6; SIR2-like protein 6; NAD-dependent protein deacetylase sirtuin-6; Regulatory protein SIR2 homolog 6; Sirtuin 6;

Application:

WB

Reactivity:

Human

Dilution:

WB 1:1000~1:2000

	Western blot analysis of SIRT6 expression in Jurkat cell lysate.

Purification:

Affinity-chromatography

Specificity:

SIRT6 Antibody detects endogenous levels of SIRT6

Immunogen:

A synthesized peptide derived from human SIRT6

Description:

The Silent Information Regulator (Sir2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.