Alternative Names:

BDNF/NT-3 growth factors receptor; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B; NTRK2; TRKB;

Application:

WB IHC IP

Reactivity:

Human

Dilution:

WB 1:1000~1:2000 IHC 1:50~1:200 IP 1:50

	Western blot analysis of TrkB expression in human brain lysate.

Purification:

Affinity-chromatography

Specificity:

TrkB Antibody detects endogenous levels of TrkB

Immunogen:

A synthesized peptide derived from human TrkB

Description:

The family of Trk receptor tyrosine kinases consists of TrkA, TrkB, and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. Plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.