Alternative Names:

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SHIP-1; p150Ship; hp51CN; INPP5D; SHIP;

Application:

WB ICC/IF IP

Reactivity:

Human

Dilution:

WB 1:1000~1:2000 ICC/IF 1:50~1:200 IP 1:20

	Western blot analysis of Phospho-SHIP (Y1020) expression in (1) Raji cell lysate; (2) Raji cell treated with pervanadate lysate.

Purification:

Affinity-chromatography

Specificity:

Phospho-SHIP (Y1020) Antibody detects endogenous levels of Phospho-SHIP (Y1020)

Immunogen:

A synthesized peptide derived from human SHIP

Description:

SH2-containing inositol phosphatase 1 (SHIP1) is a hematopoietic phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP1 is a cytosolic phosphatase with an SH2 domain in its amino terminus and two NPXY Shc binding motifs in its carboxy terminus. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.