Alternative Names:

gp140trk; GP145-TrkB; GP145-TrkC; MTC; NTRK1; NTRK2; NTRK3; p140-TrkA; TRKA; TRKB; TrkB tyrosine kinase; TRKC;

Application:

WB IHC ICC/IF

Reactivity:

Human Mouse Rat

Dilution:

WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

	Western blot analysis of TrkA+B+C expression in Human fetal brain lysate.
	Immunohistochemical analysis of paraffin-embedded mouse brain, using TrkA+B+C Antibody.
	Immunofluorescent analysis of Neuro-2a cells, using TrkA+B+C Antibody.

Purification:

Affinity-chromatography

Specificity:

TrkA+B+C Antibody detects endogenous levels of TrkA+B+C

Immunogen:

A synthesized peptide derived from human TrkA+B+C

Description:

The family of Trk receptor tyrosine kinases consists of TrkA, TrkB, and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. Neurotrophin signaling through these receptors regulates a number of physiological processes, such as cell survival, proliferation, neural development, and axon and dendrite growth and patterning.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.