Alternative Names:

NOTC4; hNotch4; INT3; Notch homolog 4;

Application:

WB FC

Reactivity:

Human Mouse

Dilution:

WB 1:100~1:500 FC 1:50

	Western blot analysis of NOTCH4 expression in Mouse lung lysate.

Purification:

Affinity-chromatography

Specificity:

NOTCH4 Antibody detects endogenous levels of total NOTCH4

Immunogen:

A synthesized peptide derived from human NOTCH4

Description:

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.