Alternative Names:

CDC23; ANAPC8; APC8; Cell division cycle 23; CUT23; Cyclosome subunit 8;

Application:

WB ICC/IF

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 ICC/IF 1:50~1:100

	Western blot analysis of Cdc23/APC8 expression in (1)HepG2 cell lysate; (2)Jurkat cell lysate.

Purification:

Affinity-chromatography

Specificity:

Cdc23/APC8 Antibody detects endogenous levels of total Cdc23/APC8

Immunogen:

A synthesized peptide derived from human Cdc23/APC8

Description:

Anaphase-promoting complex subunit 8 (APC8, CDC23) is a component of the tetratricopeptide repeat (TPR) APC/C sub-complex that also includes APC3 (CDC27) and APC6 (CDC16). APC8 protein associates with APC3 and APC6 to facilitate recruitment of the APC/C coactivation subunits CDC20 and Cdh1/FZR1. Research studies suggest that APC8 protein is overexpressed in papillary thyroid cancer and acts as an important regulator of cell cycle progression and cell growth.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.