Alternative Names:

Integrin alpha-5; VLA-5; CD49e; ITGA5; FNRA;

Application:

WB IHC ICC/IF IP FC

Reactivity:

Human Mouse Rat

Dilution:

WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:50

	Western blot analysis of Integrin alpha 5 expression in Mouse heart lysate.
	Immunofluorescent analysis of MCF-7 cells, using Integrin alpha 5 Antibody.

Purification:

Affinity-chromatography

Specificity:

Integrin alpha 5 Antibody detects endogenous levels of total Integrin alpha 5

Immunogen:

A synthesized peptide derived from human Integrin alpha 5

Description:

Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.