Alternative Names:

B7-H; B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1; CD274;

Application:

WB IHC

Reactivity:

Human Mouse Rat

Dilution:

WB 1:100~1:500 IHC 1:50~1:100

	Western blot analysis of PD-L1 (CD274) expression in Ramos cell lysate.
	Immunohistochemical analysis of paraffin-embedded human thymoma, using PD-L1 (CD274) Antibody.

Purification:

Affinity-chromatography

Specificity:

PD-L1 (CD274) Antibody detects endogenous levels of total PD-L1 (CD274)

Immunogen:

A synthesized peptide derived from human PD-L1 (CD274)

Description:

Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.