Alternative Names:

FRAP; FRAP1; FRAP2; RAFT1; Rapamycin target protein; kinase mTOR;

Application:

WB

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000

	Western blot analysis of Phospho-mTOR (S2481) expression in (1)293 cell lysate treated with LP; (2)293 cell lysate.

Purification:

Affinity-chromatography

Specificity:

Phospho-mTOR (S2481) Antibody detects endogenous levels of total Phospho-mTOR (S2481)

Immunogen:

A synthesized peptide derived from human Phospho-mTOR (S2481)

Description:

An atypical kinase belonging to the PIKK family of kinases. Controls cell growth through protein synthesis regulation. Downstream of PI3K/Akt pathway and required for cell survival. Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.