Alternative Names:

EC 2.7.10.2 p150 c-ABL Abelson murine leukemia viral oncogene homolog 1/EC 2.7.10.2 Abelson murine leukemia viral oncogene homolog 2 Abelson-related gene protein Tyrosine kinase ARG

Application:

WB IHC

Reactivity:

Human, Mouse

Dilution:

WB 1:500-1:2000 IHC 1:50-1:200

	Western blot analysis of Abl phosphorylation expression in Adriamycin treated COS7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

Purification:

Affinity-chromatography

Specificity:

Phospho-Abl (Tyr412) Antibody detects endogenous levels of Abl only when phosphorylated at Tyrosine 412

Immunogen:

A synthesized peptide derived from human Abl around the phosphorylation site of Tyrosine 412

Description:

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.