Alternative Names:

APC, APC protein, Adenomatous polyposis coli protein, DP2.5, mAPC

Application:

WB IHC

Reactivity:

Human,

Dilution:

WB 1:500-1:2000 IHC 1:50-1:200

	Western blot analysis on HuvEc cell lysate using Phospho-APC(Ser2054) Antibody

Purification:

Affinity-chromatography

Specificity:

Phospho-APC(Ser2054) Antibody detects endogenous levels of APC only when phosphorylated at Sersine 2054

Immunogen:

A synthesized peptide derived from human APC around the phosphorylation site of Sersine 2054

Description:

This gene encodes a tumor suppressor protein that includes among its many intracellular functions one of nuclear export. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.