Alternative Names:

ATF1, Activating transcription factor 1, Cyclic-AMP-dependent transcription factor ATF-1, TCR-ATF1, TREB36 protein

Application:

WB

Reactivity:

Human, Mouse

Dilution:

WB 1:500-1:2000

	Western blot analysis of ATF1 phosphorylation expression in Insulin treated HT29 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

Purification:

Affinity-chromatography

Specificity:

Phospho-ATF1 (Ser63) Antibody detects endogenous levels of ATF1 only when phosphorylated at Serine 63

Immunogen:

A synthesized peptide derived from human ATF1 around the phosphorylation site of Serine 63

Description:

ATF-1 a transcription factor that is a member of the leucine zipper family. Forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. Binds the Tax-responsive element (TRE) of HTLV-I. Activated downstream of IL-1. c-Src and TRAF6 are mediators of IL-1-induced AP-1 activation.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.