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Details
Alternative Names:
CASP-1, EC 3.4.22.36, ICE, IL-1 beta converting enzyme, IL-1BC, IL1BCE, caspase-1, interleukin-1 beta convertase, interleukin-1 beta converting enzyme, p45
Application:
WB
Reactivity:
Human,Mouse
Dilution:
WB 1:500-1:2000
Western blot analysis of Caspase 1 (Phospho-Ser376) expression in 293 cells | |
Purification:
Affinity-chromatography
Specificity:
Caspase 1 (Phospho-Ser376) Antibody detects endogenous levels of total Caspase 1 (Phospho-Ser376)
Immunogen:
A synthesized peptide derived from human Caspase 1 (Phospho-Ser376)
Description:
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Storage Condition and Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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