Alternative Names:

BING2, Death domain-associated protein 6, EAP1, ETS1 associated protein 1, Fas DEATH domain- associated protein

Application:

WB,IHC

Reactivity:

Human,Mouse

Dilution:

WB 1:500-1:2000 IHC 1:50-1:200

	Western blot analysis of Daxx (Phospho-Ser668) expression in 293 cells

Purification:

Affinity-chromatography

Specificity:

Daxx (Phospho-Ser668) Antibody detects endogenous levels of total Daxx (Phospho-Ser668)

Immunogen:

A synthesized peptide derived from human Daxx (Phospho-Ser668)

Description:

Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.