Alternative Names:

AF-1p protein; AF1P; EP15; epidermal growth factor receptor pathway substrate 15 (AF1p); epidermal growth factor receptor substrate 15

Application:

WB

Reactivity:

Human, Mouse, Rat

Dilution:

WB 1:500-1:2000

	Western blot analysis on HepG2 cell lysate using Phospho-EPS15(Tyr849) Antibody

Purification:

Affinity-chromatography

Specificity:

Phospho-EPS15(Tyr849) Antibody detects endogenous levels of EPS15 only when phosphorylated at Tyrosine 849

Immunogen:

A synthesized peptide derived from human EPS15 around the phosphorylation site of Tyrosine 849

Description:

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.