Alternative Names:

kinase EGFR; ERBB1; Epidermal growth factor receptor precursor;

Application:

WB IHC ICC/IF

Reactivity:

Human

Dilution:

WB 1:500~1:1000 IHC 1:50~1:200 ICC/IF 1:50~1:100

	Western blot analysis of EGFR(L858R) expression in (1) HeLa cell lysate; (2) H1975 cell lysate.

Purification:

Affinity-chromatography

Specificity:

EGFR(L858R mutation) Antibody detects endogenous levels of total EGFR(L858R mutation)

Immunogen:

A synthesized peptide derived from human EGFR(L858R mutation)

Description:

EGFR is a receptor tyrosine kinase. Receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. . A single-pass transmembrane tyrosine kinase. Ligand binding to this receptor results in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecules and lysosomal degradation.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.