Alternative Names:

Protein lin-28 homolog A; LIN28A; CSDD1; LIN28; ZCCHC1;

Application:

WB IHC ICC/IF IP FC

Reactivity:

Human

Dilution:

WB 1:1000~1:5000 IHC 1:50~1:200 ICC/IF 1:100~1:500 IP 1:50 FC:1:50

	Western blot analysis of LIN28 expression in NCCIT cell lysate.

Purification:

Affinity-chromatography

Specificity:

LIN28 Antibody detects endogenous levels of total LIN28

Immunogen:

A synthesized peptide derived from human LIN28

Description:

Involved in the timing of developmental events and choice of stage specific cell fates. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.