Alternative Names:

JHDM3A; JMJD2; JMJD2A; KDM4A; TDRD14A;

Application:

WB IHC IP

Reactivity:

Human Mouse Rat

Dilution:

WB 1:500~1:2000 IHC 1:50~1:200 IP 1:60

	Western blot analysis of KDM4A / JHDM3A / JMJD2A expression in (1) HEK293 cell lysate; (2) NIH3T3 cell lysate.

Purification:

Affinity-chromatography

Specificity:

KDM4A / JHDM3A / JMJD2A Antibody detects endogenous levels of total KDM4A / JHDM3A / JMJD2A

Immunogen:

A synthesized peptide derived from human KDM4A / JHDM3A / JMJD2A

Description:

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues.

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.